Material Safety Data Sheet
Biogen, Inc. 24-Hour Emergency Phone:
14 Cambridge Center 1 (800) 262 4363
Cambridge, MA 02142 Biogen Environmental Health & Safety:
(617) 679-2000 1 (617) 679 2236
Section 1. Identification
Product Name: BIO 1673
Chemical Name: BIO1673
CAS Number: None
Substance: BIO1673 is a dicarboxylic acid salt.
Other Names or Code Numbers: BG9694
Section 2. Composition / Information on Ingredients
Components % Optional OSHA PEL ACGIH TLV OTHER STANDARDS
BIO1673 98% n/a n/a none
The carboxylic acids of BIO1673 are neutralized with 2 equivalents of
tromethamine to form the salt. There are no impurities at concentration >0.5%.
Section 3. Hazards Identification
General Statement: CAUTION: THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES OF THIS MATERIAL HAVE NOT BEEN
THOROUGHLY INVESTIGATED. EXERCISE CARE TO PREVENT
CONTACT OR EXPOSURE.
Carcinogen Status: OSHA: No NTP: No IARC: No
Carcinogen Statement:
Mutagenic Effects: No data available.
Teratogenic Effects: No data available.
Reproductive Effects: No data available.
Neurotoxic Effects: No data available.
Section 4. First Aid Measures
If Inhaled: Remove to fresh air. Get medical attention. If
breathing has stopped, give artificial respiration.
Treat symptomatically and supportively.
If Swallowed: No data available. Wash mouth out with water and seek
medical attention.
In Case of Skin or Eye Contact: No data available. Irritant effects
are possible. Flush at least 15 minutes with water.
Wash skin with soap and water. contact a physician if
irritation persists.
Skin Absorption: No data available. Skin absorption is not expected.
If Injected: No data available.
Medical Conditions Aggravated by Exposure:
Note to Physician: BIO 1673 is an antiinflammatory
agent under study for the treatment of asthma.
Section 5. Fire Fighting Measures
Flash Point: no data available
Flammable Limits: no data available
Extinguishing Media: Use water spray, CO2, ABC Dry Chemical, or foam.
Special Fire Fighting Materials: No special procedures or materials.
Unusual Fire and Explosion Hazards: No data available.
Section 6. Accidental Release Measures
No data available.
Section 7. Handling and Storage
No data available for safety in handling and storage. Product stability is
ensured by storing in a sealed, dessicated container at 2-8 C.
Section 8. Exposure Control / Personal Protection
CAUTION: THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPERTIES OF THIS
MATERIAL HAVE NOT BEEN THOROUGHLY INVESTIGATED. EXERCISE CARE TO PREVENT
CONTACT OR EXPOSURE.
Perform work in a chemical fume hood or Type llB Biological Safety Cabinet
whenever possible.
Follow procedures to minimize the formation of aerosols, the potential for
direct skin or mucous membrane contact, or the potential for exposure by
inhalation or ingestion.
Use personal protective equipment such as lab coat, gloves, safety glasses
or goggles. Wash hands immediately upon removing gloves.
Section 9. Physical and Chemical Properties
Molecular Formula: C44H70N8O15
Molecular Weight: 950
Appearance/Odor: Off white to white solid/odorless
Solubilities: water/NaCl 0.9%
Boiling Point: No data avilable.
Melting Point: No data available.
Vapor Pressure(mm Hg): No data available.
Vapor Density(Air=1): No data available.
Specific Gravity (H20 = 1): No data available.
pH: 6 - 7 in water or normal saline
Section 10. Stability and Reactivity
BIO1673 is Stable
Hazardous Polymerization: Will not occur
Incompatible Materials: No data available
Conditions to Avoid: No data available.
Hazard Decomposition Products: No data available.
Section 11. Toxicology Information
CAUTION: The chemical, physical, and toxicological properties of this
product have not been thoroughly investigated. Exercise due care.
Bio 1673 is non-irritating based on single dose dermal irritation studies
on albino rabbits.
Bio 1673 is slightly irritating based on primary occular irritation
potential (Draize) tests on New Zealand White rabbits. All irritation was
reversible and completely subsided on or before day 3 post-instillation.
Results of Salmonella typhimurium/Escherichia coli Plate Incorporation
Mutation Assay showed there was no toxicity observed up to a concentration
of 2700 ug/plate. Bio 1673 was negative in this test.
Bio 1673 was negative in activated and non-activated systems tested in the
Chromosome Aberration Assay in human peripheral blood lymphocytes.
Section 12. Ecological Information
No data available
Section 13. Disposal Considerations
BIO1673 is not a regulated hazardous material. It is water soluble and
may be disposed of as aqueous waste in accordance with state and local
regulatory requirements.
Section 14. Transport Information
DOT Proper Shipping Name: n/a
Hazard Class: none
ID #: n/a
Section 15. Regulatory Information
No data available
Section 16. Other Information
MSDS Created: 23-Aug-96
Revised: 16-May-97
Prepared By: Susan Lee, CIH
Manager Environmental Health and Safety
DISCLAIMER: The above mentioned data are based on Biogen's best present
knowledge of this product. Biogen cannot guarantee completeness or
accuracy of the information contained herein, and disclaims all liability
for incompleteness or inaccuracy of the information and for any claims of
damages arising from handling or use of this product.