Material Safety Data Sheet

Biogen, Inc.                                   24-Hour Emergency Phone:
14 Cambridge Center                            1 (800) 262 4363
Cambridge, MA 02142                            Biogen Environmental Health & Safety:
(617) 679-2000                                 1 (617) 679 2236                                                                        

Section 1. Identification
Product Name:  BIO1211
Chemical Name: 
CAS Number:  None
Substance:  BIO 1211 is classified as an organic acid. 
Other Names or Code Numbers:  BG9587

Section 2.   Composition / Information on Ingredients
Components  % Optional    OSHA PEL   ACGIH TLV    OTHER STANDARDS

 BIO 1211       98%         n/a         n/a            n/a

No impurities >0.5%.  No hazardous components, as defined by the OSHA 
Hazard Communication standard (29 CFR 1910.1200), at concentrations > 1%.

Section 3. Hazards Identification
General Statement:  CAUTION: The chemical, physical, and toxicological 
properties of BIO 1211 have not been thoroughly investigated.  Exercise 
due care to prevent contact or exposure.

Carcinogen Status:   OSHA: No   NTP: No   IARC: No

Carcinogen Statement: 

Mutagenic Effects: Negative results in the Salmonella typhimurium Plate
Incorporation Mutation Screen.

Teratogenic Effects: Initial screens conducted in rats at dose levels up 
to 100 mg/kg showed no effect on fertility or fetal development.

Reproductive Effects: Initial screens conducted in rats at dose levels up 
to 100 mg/kg showed no effect on fertility or fetal development.

Neurotoxic Effects:  No data available.

Section 4.  First Aid Measures
If Inhaled:  Remove to fresh air.  Get medical attention.   If breathing 
has stopped, give artificial respiration.  Treat symptomatically and 
supportively.

If Swallowed:  Wash out with water.

In Case of Skin or Eye Contact:  Irritant effects may occur in the eye.  
Flush at least 15 minutes with water.  Wash skin with soap and water, 
Contact a physician if irritation persists.

Skin Absorption:  No data available.

If Injected:  No data available.

Medical Conditions Aggravated by Exposure:  No data available.

Section 5.  Fire Fighting Measures
Flash Point: No data available
Flammable Limits: No data available  
Extinguishing Media: Use water spray, CO2, ABC dry chemical, or foam.
Special Fire Fighting Materials: No special procedures.
Unusual Fire and Explosion Hazards:  No data available.

Section 6.  Accidental Release Measures
Spill/Leak Procedures:  Pick up solid material, dispose in closed 
container, or dissolve in water and dispose in sanitary sewer.  Flush area 
with water and dispose in sanitary sewer.  Wear gloves,safety glasses or 
goggles, and lab coat or coveralls to prevent contact.

Section 7. Handling and Storage 
Storage:  BIO1211 is moisture sensitive, degrades over period of weeks at 
90% humidity conditions.  Store desiccated at 2-8 °C.

Section 8. Exposure Control / Personal Protection
Perform work in a chemical fume hood or Type IIB biological Safety 
Cabinet, whenever possible.

Follow procedures to minimize the formation of aerosols, the potential for 
direct skin or mucous membrane contact, or the potential for exposure by 
ingestion.

Use personal protective equipment such as lab coat, gloves, safety glasses 
or goggles.  Wash hands immediately upon removing gloves.

Section 9. Physical and Chemical Properties
Molecular Formula: C36H48N6O9

Molecular Weight: approximately 708

Appearance/Odor: odorless white solid; formulated material is a clear 
aqueous solution.

Solubilities:  water: 0.08 mg/mL
sodium phosphate buffer: 50mM
dibasic sodium phosphate buffer: 200mM to 35 mg/mL
methanol, dimethylformamide

Boiling Point:  n/a
Melting Point:  decomposes 169-170 °C
Vapor Pressure (mm HG):  No data available
Vapor Density (Air = 1): No data available
Specific Gravity (H20 = 1):  No data available
pH:  0.08 mg/mL  pH =4

Section 10. Stability and Reactivity
BIO1211 is Stable
Hazardous Polymerization: Will not occur
Incompatible Materials:  No data
Conditions to Avoid: Degrades in humid environments.
Hazard Decomposition Products: No data available

Section 11. Toxicology Information
CAUTION: The chemical, physical, and toxicological properties of BIO 1211 
have not been thoroughly investigated.  Exercise due care to prevent 
contact or exposure.

BIO 1211 is classified as an organic acid.  It is in the earliest stages 
of development as an antiinflammatory agent.  

Single doses have been administered intravenously to rats(200mg/kg) and 
dogs (100mg/kg).  Preliminary results suggest that intravenous dose levels 
up to 100 mg/kg administered daily to rats for 14 days had no adverse 
effects.

See Section 3

Section 12.  Ecological Information
BIO 1211 is not a hazardous material as defined by OSHA or EPA.

Section 13. Disposal Considerations
BIO 1211 is not a regulated hazardous material.

Section 14. Transport Information
DOT Proper Shipping Name:  n/a
Hazard Class:  n/a
ID #:  n/a

Section 15. Regulatory Information
No data available.

Section 16. Other Information
MSDS Created:  26-Jul-96
Revised:       22-Apr-97
Prepared By:   Susan Lee, CIH 
               Manager, Environmental Health and Safety

DISCLAIMER: The above mentioned data are based on Biogen's best present 
knowledge of this product. Biogen cannot guarantee completeness or 
accuracy of the information contained herein, and disclaims all liability 
for incompleteness or inaccuracy of the information and for any claims of 
damages arising from handling or use of this product.